- Title
- Cancer proteomics and the elusive diagnostic biomarkers
- Creator
- Bradshaw, Ralph A.; Hondermarck, Hubert; Rodriguez, Henry
- Relation
- Proteomics Vol. 19, Issue 21-22, no. 1800445
- Publisher Link
- http://dx.doi.org/10.1002/pmic.201800445
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2019
- Description
- Despite progress in genomic and proteomic technology and applications, the validation of cancer biomarkers of use as clinical early detection diagnostics has remained elusive. As described in this brief viewpoint, there are now recognized to be many types of clinical biomarkers and proteomic analyses, particularly when combined with other ‘omic analyses, have been effective in many such biomarker identifications. However, in the area of early diagnosis of cancers, the problems associated with the conversion from identification to diagnostic have largely not been overcome. Notably, the Clinical Proteomic Tumor Analysis Consortium (CPTAC) of the National Cancer Institute (NCI), has been particularly successful in refining the analytical steps needed to tackle this challenging issue and has provided positive insight into how to solve many of the underlying problems. The potential for developing clinical diagnostics for early detection of highly lethal cancers and possible new therapeutic strategies through proteomic analyses, as seen through these CPTAC successes, is more promising than ever.
- Subject
- biomarkers; cancer; early detection diagnostics; genomics; metabolomics; proteomics; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1464293
- Identifier
- uon:46956
- Identifier
- ISSN:1615-9853
- Rights
- This is the peer reviewed version of the following article: Bradshaw, Ralph A.; Hondermarck, Hubert; Rodriguez, Henry. “Cancer proteomics and the elusive diagnostic biomarkers”. Proteomics Vol. 19, Issue 21-22, no. 1800445 (2019), which has been published in final form at http://dx.doi.org/10.1002/pmic.201800445. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Language
- eng
- Full Text
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